2-(oxalyl-amino)-4,7-dihydro-5h-thieno[2,3-c]thiopyran-3-carboxylic acid

This compound is a synthetic small molecule belonging to the thienothiopyran class and is structurally classified as an alpha amino acid derivative. It was developed as a nonphosphorus and nonpeptide inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in negative regulation of insulin signaling. By selectively inhibiting PTP1B through structure-based design—specifically targeting Asp48 for selectivity—the compound demonstrates potential utility in modulating insulin sensitivity and has been explored as a lead for antidiabetic drug development. The molecular formula is C10H9NO5S2 with an average mass of approximately 287.31 g/mol. It remains experimental with no approved indications or advanced clinical trials reported to date[1][3][8].

Other names

2-(oxalyl-amino)-4,7-dihydro-5h-thieno[2,3-c]thiopyran-3-carboxylic acid2-(carboxyformamido)-4H,5H,7H-thieno[2,3-c]thiopyran-3-carboxylic acid2-(carboxycarbonyl)amino]-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid5H-Thieno[2,3-c]thiopyran-3-carboxylic acid, 2-[carboxycarbonyl)amino]-4,7-dihydro-